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KMID : 0365819740140020227
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Journal of Pusan Medical College
1974 Volume.14 No. 2 p.227 ~ p.234
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Effects of Interruption of Pulmonary Blood Flow on Pulmonary Surface Activity in Rabbits
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Abstract
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The effect of interruption of pulmonary blood flow on pulmonary surface activity was examined in rabbits. The pulmonary blood flow was interrupted and produced atelectatis by the ligation of pulmonary artery, ligation of main-stem bronchus and both. The pulmonary surfac° tensions of these experimental lung extracts were measured from three hours to fifty days after operation and observed the cnange of surface activity by the difference of stability index between the experimental and control lung extracts.
The results were as follows.
1. In animals sacrificed three hours after pulmonary artery ligation, there was a slight decrease in the surface activity which was striking after ten hours in experimental lung. However, these decrease of surface activity in experimental lung extracts was returned to normal level fifty days after operation. The mean difference in extract stability index of both experimental and control lung extracts from rabbits sacrificed between ten hours and fourty days after pulmonary artery ligation was 0.30±0.091. This is sifnificantly different from zero.
2. In animals of left main-stem bronchial ligation, there was a remarkable decrease in surface activity after 24 hours in experimental lung and these decrease was returned to normal level 40 days after operation even in airless state.
3. In animls of both pulmonary artery and main-stem bronchial ligation, the decrease of surface activity in experimental lung extracts was prominent after ten hours from operation and these decrease was continued to 30 days after operation without return to normal level.
4. The prophylactic administration of CDP-choline seemed to have some effect to control the decrease of surface activity in impairment of pulmonary blood flow. In present experiments, it was suggested that the decrease of surface activity in atelectatic lung may be due, at least in part, to the interruption of pulmonary blood flow.
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